Mapping of Potential Variation of Diabetes Amelioration Activity of Spondias mombin on Alloxan-induced Diabetic Wister Rat Concerning the Availability of Phytochemical Constituents Based on Seasonal Contrast Phenomenon

Diabetes mellitus is the seventh leading cause of death globally, and it a disease that progressing with deadly implications on global scale. Furthermore, treatment regimen not affordable to all socioeconomic groups. As result, scientists are working develop cheaper, more effective phytochemical-based medications. Spondias mombin tree flowering plant in Anacardiaceae family commonly known as “tapereba” or “caja” Brazil. It found both Atlantic Forest Amazon upland floodplain forest environments, also present inhabited areas, albeit sub-spontaneous state. The purpose this study was determine anti-diabetic properties crude ethanol extracts obtained three seasons year: following winter, summer, rainy season. goal which season year under consideration has most action, change body weight, serum lipid profile. effects were assessed using one-touch glucometer after administration 500 mg/kg doses from each seasonal extract at time intervals: 1h, 2h, 4h, 6h, 12h, 24h, 72h. showed optimum efficacy profile dose mg/kg. However, winter summer did show any significant benefits diabetes profiles. This discovered vary seasonally.